Journal: bioRxiv
Article Title: Dysregulated tissue-resident lymphocytes drive senile emphysema by impairing alveolar regeneration
doi: 10.64898/2026.04.22.720146
Figure Lengend Snippet: ( A ) CellChat analysis of TRL subset interactions with AT2s. ( B ) Heatmap showing the interactions of IFNγ and OSM signaling pathways from TRL subsets to AT2s, analyzed by CellChat. ( C ) Plots showing the expression of Osm and Ifng in young and aged TRL subsets. ( D ) Images of organoids derived from AT2s of young mice co-cultured with TRL subsets from young or aged mice. ( E and F ) Quantification of colony-forming efficiency (CFE) and organoid size. ( G ) Images of organoids derived from AT2s of young mice treated with recombinant OSM or IFNγ. ( H and I ) Quantification of colony-forming efficiency (CFE) and organoid size.
Article Snippet: Where applicable, 1 ng/mL recombinant mouse IFNγ (Cat#BE0055-1MG; BioXcell) and 20 ng/mL recombinant mouse OSM (Cat#50112-M08H; SinoBiological) were added to the medium.
Techniques: Protein-Protein interactions, Expressing, Derivative Assay, Cell Culture, Recombinant